2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B2157S
    Robenidine-d8 hydrochloride
    		Inhibitor 99.0%
    Robenidine-d8 (hydrochloride) is the deuterium labeled Robenidine hydrochloride. Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.
    Robenidine-d<sub>8</sub> hydrochloride
  • HY-B0147
    Pefloxacin
    		Inhibitor 99.79%
    Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies.
    Pefloxacin
  • HY-N4307
    Laetanine
    		Inhibitor
    Laetanine is a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity. Laetanine can be found in the extract of the leaves of Phoebe tavoyana (Meissn) Hook.
    Laetanine
  • HY-12640R
    Pyrantel pamoate (Standard)
    		Inhibitor
    Pyrantel (pamoate) (Standard) is the analytical standard of Pyrantel (pamoate). This product is intended for research and analytical applications. Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.
    Pyrantel pamoate (Standard)
  • HY-B1221S1
    Flufenamic acid-13C6
    		Inhibitor
    Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
    Flufenamic acid-<sup>13</sup>C<sub>6</sub>
  • HY-107566
    Conessine
    		Inhibitor 99.87%
    Conessine is an orally active and BBB-penetrable selective histamine H3 receptor antagonist. The pKi values of Conessine for rat and human H3 receptors are 7.61 and 8.27, respectively. Conessine is an inhibitor of the multidrug efflux pump system in Pseudomonas aeruginosa and can enhance the activity of antibiotics. Conessine has antimalarial activity. Conessine can also be used in the research of muscle atrophy.
    Conessine
  • HY-17592A
    Bithionol (sulfoxide)
    		Inhibitor 99.02%
    Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection.
    Bithionol (sulfoxide)
  • HY-N12210
    Notrilobolide
    		Inhibitor
    Notrilobolide is an alkaloid with insecticidal properties isolated from sweet potatoes. Notrilobolide has an inhibitory effect on the larval development of pests such as Tribolium Castaneum, affecting the digestion and reproduction of insects by inhibiting the fecundity of pests.
    Notrilobolide
  • HY-125159
    Derquantel
    		Inhibitor 98.4%
    Derquantel is a potent anthelmintic. Derquantel causes flaccid paralysis and expulsion of nematodes.
    Derquantel
  • HY-N7926
    Pentadecane
    		Inhibitor 98.88%
    Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC50s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities.
    Pentadecane
  • HY-N7516
    4'-Hydroxy-2,4-dimethoxychalcone
    		Inhibitor 99.76%
    4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity.
    4'-Hydroxy-2,4-dimethoxychalcone
  • HY-B0836R
    λ-Cyhalothrin (Standard)
    		Inhibitor
    λ-Cyhalothrin (Standard) is the analytical standard of λ-Cyhalothrin. This product is intended for research and analytical applications. λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system.
    λ-Cyhalothrin (Standard)
  • HY-N4238
    Dehydrocorydaline nitrate
    		Inhibitor 99.90%
    Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
    Dehydrocorydaline nitrate
  • HY-N2848
    α-Lapachone
    		99.65%
    α-Lapachone shows trypanocidal activity.
    α-Lapachone
  • HY-N2795
    9-Hydroxycalabaxanthone
    		Inhibitor 99.14%
    9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM).
    9-Hydroxycalabaxanthone
  • HY-134454
    Z-Pro-Pro-CHO
    		Inhibitor 98.03%
    Z-Pro-Pro-CHO is a prolyl oligopeptidase inhibitor (IC50: 0.16 μM and 0.01 μM for human and Schistosoma Mansoni prolyl oligopeptidase respectively).
    Z-Pro-Pro-CHO
  • HY-N12093
    Cevadine
    		Inhibitor 98.76%
    Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity.
    Cevadine
  • HY-17532
    Haloxon
    		Inhibitor 98.0%
    Haloxon is an anti-parasitic agent. Haloxon can be used for the research of infections of Parascaris equorum, Oxyuris equi and Strongylus vulgaris. Haloxon also can be used in control of ascarids and hookworms in domesticated animals in combination with Bidimazium.
    Haloxon
  • HY-108938
    SDZ285428
    		Inhibitor 98.00%
    SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h).
    SDZ285428
  • HY-136438
    Toltrazuril sulfoxide
    		Inhibitor 99.55%
    Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
    Toltrazuril sulfoxide
Parasite Isoform Comparison

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